Amyloid Precursor Protein (APP) (1-16) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Peptide ELISA: 1/8000 (detection limit). Western Blot: 1-3 µg/ml. Detects a band of Approx 75kDa in Human Brain (Cerebral and Frontal cortex) lysates and in Mouse adult and fetal Brain lysates.
Reactivity	Bovine, Canine, Human, Porcine
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence DAEFRHDSGYEVHHQK-C, from the N-Terminus of the protein sequence according to NP_000475.1; NP_958816.1; NP_958817.1; NP_001129601.1; NP_001129602.1.
Specificity	This antibody is expected to recognize all reported isoforms of APP (NP_000475.1, NP_958816.1, NP_958817.1, NP_001129601.1, NP_001129602.1) and to recognize all lengths of the Amyloid beta peptide.
Formulation	Tris saline, pH~7.3 State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 0.5% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	78.7 kDa (NP_958817.1) and 72.6 (NP_001129601.1).
Gene Name	amyloid beta precursor protein
Database Link	Entrez Gene 351 Human UniProt ID P05067
Background	Amyloid Precursor Protein (APP) ,with 32-amino acid protein (about 35 kDa), is part of a super-family of transmembrane and secreted proteins. It appears to have a number of roles, including regulation of haemostasis and mediation of neuroprotection. APP undergoes alternative splicing, resulting in several isoforms . Proteolytic cleavage of amyloid precursor protein leads to the formation of the 4 kDa amyloid beta/A4 protein, which is present in human platelets. APP is also involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer patients.
Synonyms	Alzheimer disease amyloid protein, Amyloid Precursor Protein, ABPP, APPI, PreA4, Cerebral vascular amyloid peptide, CVAP
Reference Data

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