CHMP4B Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1/200-1/5000. Immunohistochemistry: 1/100-1/2000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant Human CHMP4b protein.
Specificity	Recognizes CHMP4b.
Formulation	0.1M Tris, 0.1M Glycine, 2% Sucrose State: Purified State: Lyophilized powder Preservative: None
Reconstitution Method	Restore in distilled water
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibody at 2-4°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	charged multivesicular body protein 4B
Database Link	Entrez Gene 128866 Human UniProt ID Q9H444
Background	The charged multivesicular body proteins or chromatin modifying proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), and are also required for the formation of these bodies. CHMP4B (charged multivesicular body protein 4b) is a 224 amino acid protein that interacts with Alix, which results in the redistribution of Alix from the cytoplasm to the perinuclear area. Overexpression of CHMP4B induces accumulation of ubiquinated proteins and inhibits degradation of endocytosed EGF. Defects in the gene encoding CHMP4B can cause posterior polar cataract type 3 (CTPP3), a disease characterized by distinct opacity located at the back of the lens resulting in visual impairment and eventual blindness.
Synonyms	C20orf178, SHAX1, CHMP4b, SNF7-2, hSnf7-2, Vps32-2, hVps32-2
Reference Data

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