KCNC3 Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Peptide ELISA: 1/64000 (Detection Limit). Western blot: 0.2-0.6 µg/ml. A band of ~80kDa is observed in Mouse fetal Brain lysates. Some minor background is detected and is blocked by the immunizing peptide. We call for caution when used for other assays than Western blot.
Reactivity	Mouse, Porcine, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence from the internal region of the protein sequence according to NP_032448.2.
Specificity	This antibody recognizes Mouse Kcnc3/Kv3.3
Formulation	Tris buffered saline, pH~7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Database Link	UniProt ID Q63959
Background	KCNC3 mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
Synonyms	Potassium voltage-gated channel subfamily C member 3, Voltage-gated potassium channel subunit Kv3.3, KSHIIID
Note	Calculated Molecular Weight: 81.9kDa (NP_032448.2)
Reference Data

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