JAB1 (COPS5) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 1/100. Western Blot: 1 - 2 µg/ml.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide from N-terminal of human JAB1 protein
Specificity	This antibody reacts to the N-term of 38 Kda Mov34 Isologue (COPS5).
Formulation	10 mM PBS, pH 7.4 containing BSA as stabilizer and 0,09% sodium azide as preservative State: Purified State: Liquid purfied Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	COP9 signalosome subunit 5
Database Link	Entrez Gene 26754 MouseEntrez Gene 312916 RatEntrez Gene 10987 Human UniProt ID Q92905
Background	Jun activation domain-binding protein-1 (JAB1) also designated COP9 subunits 5 (COPS5) or SGN5 is a coactivator of AP-1 transcription factor that also promotes degradation of the cyclin-dependent kinase inhibitor p27Kip1. JAB1 interacts with c-Jun AP-1 containing complexes, and enhances transactivation from AP-1-dependent promoters. JAB1 is highly conserved in evolution and is widely expressed in mammalian tissues. It is localized both the nucleus and the cytoplasm.
Synonyms	Signalosome subunit 5, SGN5, CSN5, JAB1
Reference Data
Protein Families	Druggable Genome, Protease, Transcription Factors

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