Caspase 3 (CASP3) (29-33) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1:1000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide sequence around aa.29~33 derived from Caspase 3
Specificity	This antibody detects endogenous level of total Caspase 3 protein.
Formulation	Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Affinity-chromatography using epitope-specific peptide
Conjugation	Unconjugated
Storage Condition	Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Gene Name	caspase 3
Database Link	Entrez Gene 836 Human UniProt ID P42574
Background	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
Synonyms	CASP-3, CASP3, CPP32, CPP-32, Yama protein, Apopain, SCA-1, SCA1
Note	Molecular weight: 35/19/17 kDa
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Protease
Protein Pathways	Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Epithelial cell signaling in Helicobacter pylori infection, Huntington's disease, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Parkinson's disease, Pathways in cancer, Viral myocarditis

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