Cytochrome P450 26B (CYP26B1) (160-396) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 10 µg/ml. Western Blot: 1/500 - 1/3000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein fragment containing a sequence corresponding to a region within amino acids 160 and 396 of Human Cytochrome P450 26B
Specificity	This antibody recognizes CYP26B1 at aa160-396.
Formulation	0.1M Tris-glycine, pH 7, 20% Glycerol and 0.01% Thimerosal State: Aff - Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	cytochrome P450 family 26 subfamily B member 1
Database Link	Entrez Gene 232174 MouseEntrez Gene 312495 RatEntrez Gene 56603 Human UniProt ID Q9NR63
Background	Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival.
Synonyms	CYP26A2, Cytochrome P450RAI2, Cytochrome P450 26B1, Cytochrome P450 26A2
Reference Data
Protein Families	Druggable Genome, P450
Protein Pathways	Retinol metabolism

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