MMP16 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: At 1-2μg/ml with the appropriate system to detect MMP16 in cells and tissues. Immunohistochemistry on paraffin sections: At 0.5-1μg/ml to detect MMP16 in formalin fixed and paraffin embedded tissues. Immunohistochemistry on frozen sections: At 0.5-1μg/ml to detect MMP16 in formalin or acetone fixed tissues.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide mapping at the C-terminal of human MMP16
Specificity	This antibody detects MMP-16 at C-term.
Formulation	5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3 State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	0.2ml of distilled water will yield a concentration of 500μg/ml.
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	matrix metallopeptidase 16
Database Link	Entrez Gene 17389 MouseEntrez Gene 65205 RatEntrez Gene 4325 Human UniProt ID P51512
Background	The matrix metalloproteinase 16(MMP16) protein consists of 604 amino acids and has a characteristic MMP domain structure, which gene is mapped on human chromosome 8q211. Additionally, MMP16 has a C-terminal extension containing a potential transmembrane domain, similar to MMP14 , MMP15 , and MMP172. Furthermore, it is membrane-bound and is a member of the membrane-type MMPs that are a subclass in the MMP family since the other members lack a C-terminal transmembrane domain and are secreted as soluble forms. MMP16 is expressed as a 12-kb transcript in brain, placenta, heart, and some carcinoma cell lines, but is not detectably expressed in lung, kidney, liver, spleen, and muscle.
Synonyms	Matrix metalloproteinase-16, MMP-X2, MMP16, MMPX2, Membrane-type-3 matrix metalloproteinase
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein, Transmembrane

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