CHRNA1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 0.75 μg/ml. Immunohistochemistry on Paraffin Sections (1-2.0 μg/ml). Antigen retrieval by heat is recommended.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminal of Human CHRNA1, identical to the related Rat and Mouse sequence
Specificity	Recognizes CHRNA1
Formulation	5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal and 0.05mg Sodium Azide State: Aff - Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with 0.2 ml of distilled water to yield a concentration of 0.5 mg/ml.
Concentration	0.5 mg/ml (after reconstitution)
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody after reconstitution at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cholinergic receptor nicotinic alpha 1 subunit
Database Link	Entrez Gene 11435 MouseEntrez Gene 79557 RatEntrez Gene 1134 Human UniProt ID P02708
Background	CHRNA, also termed ACHRA, is mapped on 2q24-q32.This gene encodes the alpha subunit of the muscle acetylcholine receptor, which is the main target of pathogenic autoantibodies in autoimmune myasthenia gravis. (1) The protein-coding sequence of the human alpha subu gene is divided into 9 exons that correspond to different structural and functional domains of the precursor molecule. (2)
Synonyms	CHRNA1, ACHRA, CHNRA
Reference Data
Protein Families	Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane

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