FGFR2 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: Use at 1 μg/ml with the appropriate system to detect FGFR2 in cells and tissues. Immunohistochemistry on Paraffin Sections: Use at 2 μg/ml to detect FGFR2 in Formalin Fixed and Paraffin Embedded tissues (Antigen Retrieval by heat is required).
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminal of Human FGFR2, identical to the related Rat and Mouse sequence.
Specificity	Recognizes CD332 / FGFR-2. No cross reactivity with other proteins.
Formulation	5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal and 0.05mg Sodium Azide State: Aff - Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with 0.2 ml of distilled water to yield a concentration of 0.5 mg/ml.
Concentration	0.5 mg/ml (after reconstitution)
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody after reconstitution at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	fibroblast growth factor receptor 2
Database Link	Entrez Gene 14183 MouseEntrez Gene 25022 RatEntrez Gene 2263 Human UniProt ID P21802
Background	Fibroblast growth factor receptor 2 (FGFR2) is a receptor for fibroblast growth factor encoded on a gene residing on chromosome 10. FGFR2 has also been designated as CD332. FGFR2 is a membrane-spanning tyrosine kinase that serves as a high affinity receptor for several members of the fibroblast growth factor (FGF) family. Its signals are absolutely required for vertebrate limb induction and that an FGFR2 signal is essential for the reciprocal regulation loop between FGF8 and FGF10 during limb induction. (1) FGFR2 contributes to the outgrowth, differentiation, and maintenance of the inner cell mass and raise the possibility that this activity is mediated by FGF4 signals transmitted by FGFR2. The role of early FGF signaling in pregastrulation development as a possible adaptation to mammalian (amniote) embryogenesis is discussed. (2)
Synonyms	FGFR2, BEK, KGFR, KSAM
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Secreted Protein, Transmembrane
Protein Pathways	Endocytosis, MAPK signaling pathway, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton

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