Endothelin B Receptor (EDNRB) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1 μg/ml.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to a sequence in the middle region of Human EDNR-B (244-258aa).
Specificity	This antibody detects Endothelin B Receptor. No cross reactivity with other proteins.
Formulation	5mg BSA, 0.9mg Nacl, 0.2mg Na2HPO4, 0.05mg Thimerosal and 0.05mg Sodium Azide State: Aff - Purified State: Lyophilized purified Ig fraction
Reconstitution Method	0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Purification	Immunogen Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	endothelin receptor type B
Database Link	Entrez Gene 1910 Human UniProt ID P24530
Background	Endothelin Receptor B (EDNR-B), also called endothelin receptor, nonselective type (ETB, ETRB). It is a G-protein-coupled receptor with seven transmembrane domains which is required for the development of melanocytes and enteric neurons and migration of melanoblasts and enteric neuroblasts. The EDNRB gene spans 24 kilobases and consists of seven exons and six introns.This gene was expressed in human glaucomatous optic nerves and mapped to 13q22. The cDNA fragment for horse EDNRB contained a 1329 bp open reading frame which encoded 443 amino acid residues. The predicted amino acid sequence was 89, 91 and 85% identical to human, bovine and mouse as well as rat EDNRB respectively, but only 55% identical to the human, bovine and rat endothelin A receptor (EDNRA). EDNRB plays an essential role in the normal development of two neural crest-derived cell lineages, epidermal melanocytes and enteric neurons in three mammalian species--humans, mice, and rats. The EDNRB-deficient rat may also prove valuable in defining the postnatal physiologic role of this receptor.
Synonyms	ET-BR, ET-B, EDNRB, ETRB, ETB, ETBR, HSCR, WS4A, ABCDS, HSCR2
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.