CMA1 (96-110) Goat Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 1.5 - 3.75 µg/ml.
Reactivity	Human, Monkey
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from an internal region of human CMA1 / Mast Cell Chymase (NP_001827.1)
Specificity	This antibody detects Mast Cell Chymase (Internal).
Formulation	Tris saline, pH 7.3 containing 0.02% sodium azide as preservative and 0.5% BSA as stabilizer State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	chymase 1
Database Link	Entrez Gene 1215 Human UniProt ID P23946
Background	CMA1 / MCT1 / Chymase is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II.
Synonyms	Alpha-chymase, Mast cell protease I, CMA1, CYH, CYM
Note	Caution: The human mast cell protease I is not the same as the mouse mast cell protease I!
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein
Protein Pathways	Renin-angiotensin system

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