MET (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 15 µg/ml.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	MET antibody was raised against a synthetic peptide from C-terminus of human c-Met protein
Specificity	This antibody reacts to Hepatocyte Growth Factor Receptor (MET).
Formulation	10mM PBS/1% BSA buffer pH 7.4 with 0.09% sodium azide. State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	MET proto-oncogene, receptor tyrosine kinase
Database Link	Entrez Gene 4233 Human UniProt ID P08581
Background	Met, an HGF Receptor/Met type protein kinase, is a cell-surface proto-oncogene that mediates the biological activities of hepatocyte growth factor. The protein is a disulfide-linked heterodimer comprised of two subunits: a 50 kD extracellular alpha subunit and a membrane-spanning 145 kD beta subunit that binds ligand. Met is an important regulator of cell proliferation and differentiation, organ regeneration, embryogenesis, and tumorogenesis. Constitutive activation mutations of the met gene lead to many cancers, particularly renal papillary carcinoma.
Synonyms	Hepatocyte growth factor receptor, MET, Scatter factor receptor, HGF/SF receptor, c-Met
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways	Adherens junction, Axon guidance, Colorectal cancer, Cytokine-cytokine receptor interaction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, Focal adhesion, Melanoma, Pathways in cancer, Renal cell carcinoma

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.