GRIA4 (279-292) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/128000, 0.3 - 1 µg/ml. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 0.3 - 1 µg/ml.
Reactivity	Bovine, Human, Mouse, Rat, Bat, Canine, Chicken, Equine, Monkey, Rabbit
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with from the internal region of the protein sequence according to NP_000820.3, NP_001070711.1, NP_001070712.1
Specificity	This antibody detects Glutamate receptor 4 / GLUR4 (Internal). It is expected to recognize all reported isforms (NP_000820.3; NP_001070711.1; NP_001070712.1). Reported variants NP_001070712.1 and NP_001106283.1 represent identical protein.
Formulation	Tris saline, pH 7.3 containing 0.02% sodium azide as preservative and 0.5% BSA as stabilizer State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	glutamate ionotropic receptor AMPA type subunit 4
Database Link	Entrez Gene 2893 Human UniProt ID P48058
Background	Human glutamate receptor 4 (GRIA4) is a new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. Binding studies showed that human GRIA4 transfected into simian kidney cells (COS-1) exhibits high specific binding for[3H](RS)-alpha-amino- 3-hydroxy-5-methylisoxazole-4-propionic acid ([3H]AMPA) but not [3H]kainate. Ion substitution experiments indicate that hGluR4 receptor-linked ion channels in their homomeric state are permeable to both CA2+ and Na+ ions. Immunoprecipitation studies suggest that GRIA1 exists in situ in the form of a pentamer.
Synonyms	GluR-4, GRIA4, GluR-D, GluA4, Glutamate receptor ionotropic AMPA4
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.