PCSK9 (214-228) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Peptide ELISA: Limit Dlution: 1/16000. Western blot: 0.1-0.5 µg/ml. In transfected HEK293 transiently expressing full-length Human PCSK9 (myc and DYKDDDDK tagged), a doublet of approx. 80-100kDa was observed. No bands were observed in mock-transfected HEK293 and the same bands were observed using anti-myc tag antibody.
Reactivity	Human, Mouse, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence from the internal region of the protein sequence according to NP_777596.2.
Specificity	Recognizes PCSK9.
Formulation	Tris saline, pH~7.3 with 0.02% Sodium Azide and 0.5% BSA State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	proprotein convertase subtilisin/kexin type 9
Database Link	Entrez Gene 255738 Human UniProt ID Q8NBP7
Background	PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. PCSK9 may function as a proprotein convertase. PCSK9 plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in PCSK9 gene have been associated with a third form of autosomal dominant familial hypercholesterolemia.
Synonyms	PCSK-9, NARC1, Proprotein convertase subtilisin/kexin type 9, Proprotein convertase PC9, Subtilisin/kexin-like protease PC9, Neural apoptosis-regulated convertase 1, NARC-1
Reference Data

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