MEK7 (MAP2K7) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1/500 - 1/1000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Specificity	This antibody detects endogenous levels of MEK-7 protein. (region surrounding Ile264)
Formulation	Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide
Concentration	1.0 mg/ml
Purification	Affinity chromatography (> 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 48 kDa
Gene Name	mitogen-activated protein kinase kinase 7
Database Link	Entrez Gene 26400 MouseEntrez Gene 363855 RatEntrez Gene 5609 Human UniProt ID O14733
Background	Mitogen Activated Protein Kinase Kinase 7 (MEK 7 or MKK 7) is a 38 kDa member of a tyrosine/threonine protein kinase family that activates the c Jun NH2-terminal kinases (JNK), which is part of the inflammation/stress signaling pathway. Phosphorylation of MEK 7 by MEKK 1 on serine 271 and threonine 275 in the catalytic domain activates the protein and enables MEK 7 to phosphorylate JNK.
Synonyms	MAPK/ERK kinase 7, JNK-activating kinase 2, c-Jun N-terminal kinase kinase 2, MAPKK 7, NKK2, MEK7, MKK7, MAP kinase kinase 7
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	ErbB signaling pathway, Fc epsilon RI signaling pathway, GnRH signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway

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