DOK2 pTyr299 Rabbit Polyclonal Antibody
CAT#: AP20861PU-N
DOK2 pTyr299 rabbit polyclonal antibody, Aff - Purified
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CNY 1,999.00
CNY 4,437.00
货期*
2周
规格
Specifications
Product Data | |
Applications | IF, WB |
Recommend Dilution | Western blot: 1/500 - 1/1000. Immunofluorescence: 1/50 - 1/200. |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic phosphopeptide derived from human Dok-2 around the phosphorylation site of Tyrosine 299. |
Specificity | This antibody detects endogenous levels of Dok-2 protein when phosphorylated at Tyr299. |
Formulation | Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide |
Concentration | 1.0 mg/ml |
Purification | Affinity chromatography (> 95% (by SDS-PAGE) |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Predicted Protein Size | ~ 56 kDa |
Gene Name | docking protein 2 |
Database Link | |
Background | Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that p62 Dok-1 is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, is a member of a class of “docking” proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, Insulin and IGF. Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl. |
Synonyms | p56(dok-2), p56Dok-2, Docking protein 2 |
Reference Data | |
Protein Families | Druggable Genome |
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