Netrin 1 (NTN1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Specificity	This antibody detects endogenous levels of Netrin-1 protein. (region surrounding Gln533)
Formulation	Phosphate buffered saline (PBS), pH~7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% (by SDS-PAGE) Preservative: 0.05% Sodium Azide
Concentration	1.0 mg/ml
Purification	Affinity Chromatography using epitope-specific immunogen
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~68 kDa
Gene Name	netrin 1
Database Link	Entrez Gene 18208 MouseEntrez Gene 114523 RatEntrez Gene 9423 Human UniProt ID O95631
Background	Netrin-G1 ligand (NGL1) is a transmembrane protein containing leucine-rich repeat (LRR) and immunoglobulin (Ig) domains that specifically interact with netrin-G1 through its LRR region. Whereas netrin-G1 is expressed highly in mouse thalamic axons, NGL1 is most abundant in the striatum and the cerebral cortex. NGL1 is implicated in facilitating axonal growth of the vertebrate CNS. Membrane-bound netrin-G1 acts as an axonal receptor, whereas the LRR-containing transmembrane protein NGL1 acts as a ligand in promoting the growth of thalamic axons.
Synonyms	NTN1, NTN1L
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Axon guidance

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