GABA A Receptor alpha 1 (GABRA1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on paraffin sections: 1/50 - 1/200.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Specificity	This antibody detects endogenous levels of GABAA Ralpha1 protein. (region surrounding Leu361)
Formulation	Phosphate buffered saline (PBS), pH 7.2 State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide
Concentration	1.0 mg/ml
Purification	Affinity chromatography (> 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	gamma-aminobutyric acid type A receptor alpha1 subunit
Database Link	Entrez Gene 14394 MouseEntrez Gene 29705 RatEntrez Gene 2554 Human UniProt ID P14867
Background	GAD-65 and GAD-67, glutamate decarboxylases of 65 and 67 kDa, respectively, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Ralpha1-6, GABAA Rbeta1-3, GABAA Repsilon, GABAA Rdelta, GABAA Rgamma1-3, GABAA Rrho1 and GABAA Rrho2. The GABAB family is composed of GABAB R1alpha and GABAB R1beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2 and -3). The GABA transporters function to terminate GABA action.
Synonyms	GABRA-1, GABA A receptor subunit alpha-1
Reference Data
Protein Families	Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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