SOCS1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1/500-1/000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Specificity	This antibody detects endogenous levels of SOCS1 / JAB protein. (region surrounding Val98)
Formulation	Phosphate buffered saline (PBS), pH 7.2 State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% Sodium azide
Concentration	1.0 mg/ml
Purification	Affinity-chromatography using epitope-specific immunogen; purity is > 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 38 kDa
Gene Name	suppressor of cytokine signaling 1
Database Link	Entrez Gene 12703 MouseEntrez Gene 252971 RatEntrez Gene 8651 Human UniProt ID O15524
Background	The SOCS (suppressor of cytokine signaling) gene family consists of a group of proteins that negatively regulate cytokine signal transduction. The SOCS family proteins contain a central SH2 domain and a carboxy-terminal region termed the “SOCS box.” The SOCS-1 (also called SSI-1 and JAB), SOCS-2 (also called SSI-2 and CIS2) and SOC-3 (also called SSI-3 and CIS3) genes are known to be upregulated by IL-6 and other cytokines. SOCS-4, SOCS-5, SOCS-6 and SOCS-7 were identified by their sequence homology with the SOCS box. CIS (for cytokine-inducible SH2-containing protein) is also a member of the SOCS family.
Synonyms	Suppressor of cytokine signaling 1, SOCS-1, SSI1, SSI-1, TIP3, TIP-3, JAB
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway
Protein Pathways	Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis

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