GABA A Receptor gamma 2 (GABRG2) (400-410) Goat Polyclonal Antibody

CAT#: AP20117PU-N

GABA A Receptor gamma 2 (GABRG2) (400-410) goat polyclonal antibody, Aff - Purified



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CNY 5,371.00


货期*
4周

规格
    • 100 ug

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Specifications

Product Data
Applications ELISA, WB
Recommend Dilution Peptide ELISA: Limit Dilution: 1/16000.
Western blot: 1-3 µg/ml. Approx 50kDa band observed in Mouse and Rat Brain lysates (calculated MW of 55.1kDa according to Mouse NP_032099.1 and 54.1kDa according to Rat NP_899156.1).
Reactivity Bovine, Human, Mouse, Rat
Host Goat
Clonality Polyclonal
Immunogen Peptide with sequence from the internal region of the protein sequence according to NP_944494.1; NP_000807.2; NP_944493.2.
Specificity This antibody is expected to recognize all reported isoforms: NP_944494.1; NP_000807.2; NP_944493.2.
Formulation Tris saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer.
State: Aff - Purified
State: Liquid purified Ig fraction.
Concentration lot specific
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name gamma-aminobutyric acid type A receptor gamma2 subunit
Background GABA A receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA A. Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics.
GABA A Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics.
The binding of GABA to GABA A receptors results in the increase transportation of chlorine ions into the neuron. This influx results in signal transmission repression. Studies have shown that if cell to cell signaling goes unchecked due to a lack of GABA, a system "overload" can resulting in blackouts, rapid body contractions, seizures and epilepsy.
Synonyms GABRG-2, GABA A Receptor subunit gamma-2
Reference Data
Protein Families Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane
Protein Pathways Neuroactive ligand-receptor interaction
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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