Cytochrome p450 2C19 (CYP2C19) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 1/1000. ELISA: 1/1,000. Immunohistochemistry on Paraffin Sections: 1/10-1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 257-285 amino acids from the Central region of Human CYP2C19.
Specificity	This antibody detects CYP2C19 at Center.
Formulation	PBS with 0.09% (W/V) Sodium Azide State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cytochrome P450 family 2 subfamily C member 19
Database Link	Entrez Gene 1557 Human UniProt ID P33261
Background	CYP2C19 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within its gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes.
Synonyms	Cytochrome P450 2C19, CYPIIC17, CYPIIC19, Cytochrome P450-254C
Note	Molecular weight: 55931 Da
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Arachidonic acid metabolism, Drug metabolism - cytochrome P450, Linoleic acid metabolism, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Retinol metabolism

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