BLNK (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA:1/1,000. Western Blot: 1/100~1/500.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	This BLNK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human BLNK.
Specificity	BLNK antibody recognizes BLNK at Center.
Formulation	PBS with 0.09% (W/V) Sodium Azide as preservative State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Protein A column followed by Peptide Affinity Purification.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	B-cell linker
Database Link	Entrez Gene 29760 Human UniProt ID Q8WV28
Background	BLNK (B cell linker protein) is an adaptor molecule that plays key role in B cell activation initiated by cross-linking the B cell receptor (BCR). This activation leads to an increase in the tyrosine phosphorylation of a number of proteins due to activation of nonreceptor protein tyrosine kinases (PTK) including Syk, which is responsible for the tyrosine phosphorylation of BLNK. BLNK is cytosolic protein identified as two phosphoproteins migrating at 68 and 70 kDa in SDS/PAGE (alternatively spliced forms of human BLNK). Mapping of the tyrosine residues in BLNK reveal three tyrosines that bind PLC-gamma2, and two tyrosines that bind the Tec family kinase Btk, the Vav nucleotide exchange factor and the adaptor Nck.
Synonyms	BASH, SLP65, SLP-65
Reference Data
Protein Families	Druggable Genome
Protein Pathways	B cell receptor signaling pathway, Primary immunodeficiency

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