ABCG1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	Western blot: 1/1000. Flow Cytometry: 1/10-1/50. Immunohistochemistry: 1/10-1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 366~395 from the Center region of Human ABCG1
Specificity	This antibody detects ABCG1 at Center.
Formulation	PBS with 0.09% (W/V) sodium azide State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	ATP binding cassette subfamily G member 1
Database Link	Entrez Gene 9619 Human UniProt ID P45844
Background	ABCG1, one of five members of the ABCG subfamily, belongs to the large family of ATP-binding cassette (ABC) transporters. The protein is expressed in the plasma membrane of adipocytes, macrophages and other cell types. In these cells, ABCG1 facilitates cholesterol efflux to apoAI and/or high-density lipoprotein (HDL). The function of ABCG1 is linked to both obesity and atherosclerosis. First, studies in Abcg1 knockout mice showed that the gene deletion resulted in a significantly reduced size of fat cells. Second, the activation of ABCG1 expression promoted atherosclerotic lesion development while inactivation of macrophage ABCG1 expression reduced it in proatherogenic mice. In addition, ABCG1 plays a key role in lipoprotein formation by glia.
Synonyms	ABC8, WHT1
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	ABC transporters

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