COMT (N-term) Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Peptide ELISA: Detection Limit Dilution: 1/4000. Western Blot: 0.3-1.0 µg/ml. Approx 26kDa plus 29kDa bands observed in Human Testis lysates (calculated MW of 30.0kDa according to NP_000745.1 and of 24.5kDa according to NP_009294.1).
Reactivity	Canine, Human, Mouse, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence GDTKEQRILNHVLQC, from the N-Terminus of the protein sequence
Specificity	This antibody is expected to recognise both reported isoforms. Variants (NP_000745.1, NP_001128633.1 and NP_001128634.1) encode the same isoform.
Formulation	Tris saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer. State: Aff - Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	catechol-O-methyltransferase
Database Link	Entrez Gene 1312 Human UniProt ID P21964
Background	Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease.
Synonyms	Catechol O-methyltransferase
Reference Data

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