Hexokinase II (HK2) (Center) Rabbit Polyclonal Antibody

CAT#: AP15125PU-N

Hexokinase II (HK2) (Center) rabbit polyclonal antibody, Purified



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CNY 6,160.00


货期*
5周

规格
    • 400 ul

Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution ELISA: 1/1,000.
Western blotting: 1/100-1/500.
Immunohistochemistry: 1/50-1/100.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 409~438 amino acids from the center region of Human HK2.
Specificity This antibody detects Hexokinase-2 at Center
Formulation PBS with 0.09% (W/V) Sodium Azide as preservative.
State: Purified
State: Liquid purified Ig fraction.
Concentration lot specific
Purification Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name hexokinase 2
Background In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step in several metabolic pathways. HK3 is bound to the outer mitochondrial membrane. Its hydrophobic N-terminal sequence may be involved in membrane bindng. It is the predominant hexokinase isozyme expressed in insuline-responsive tissues such as skeletal muscle. The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated wiht the N-terminus. Although found in NIDDM patients, genetic variations of HK2 do not contribute to the disease.
Synonyms Hexokinase type II, Muscle form hexokinase, HK2, HKII
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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