MLK4 (MAP3K21) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA: 1/1,000 . Western blotting: 1/1000. Immunohistochemistry on Paraffin Sections: 1/10-1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of Human MLK4.
Specificity	This antibody recognizes MLK4 (N-term). Other species not tested.
Formulation	PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.09% (W/V) Sodium Azide
Concentration	lot specific
Purification	Saturated Ammonium Sulfate (SAS) Precipitation, followed by dialysis against PBS
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	113957 Da
Gene Name	mitogen-activated protein kinase kinase kinase 21
Database Link	Entrez Gene 84451 Human UniProt ID Q5TCX8
Background	Mixed-lineage kinases (MLKs) function as mitogen-activated protein kinase kinase kinases (MAP3Ks), activating the p38 and JNK signaling cascades. Systematic mutational analyses of tyrosine kinases reveal that a minimum of 30% of colorectal cancer contain at least one mutation in the tyrosine kinases; sampling of colorect cancer cells suggest an important role of MLK4 in this process.  Function: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
Synonyms	Mitogen-activated protein kinase kinase kinase, MLK4, KIAA1804
Reference Data

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