APPBP1 (NAE1) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA: 1/1,000. Western blot: 1/1000. Immunohistochemsitry: 1/10-1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 452-482 amino acids from the C-terminal region of human NAE1 (APPBP1).
Specificity	This antibody detects NAE1 (APPBP1) at C-term.
Formulation	PBS with 0.09% (W/V) sodium azide State: Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	NEDD8 activating enzyme E1 subunit 1
Database Link	Entrez Gene 8883 Human UniProt ID Q13564
Background	APPBP1 binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, this protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. APPBP1 is required for cell cycle progression through the S/M checkpoint.
Synonyms	NAE1, HPP1
Note	Molecular weight: 60252 Da
Reference Data

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