OLIG2 Rabbit Polyclonal Antibody

Specifications

Product Data
Recommend Dilution	ELISA. Western Blot: 1/200-1/2000. Immunohistochemistry: 1/50-1/500.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from C-terminal domain of Human OLIG2
Specificity	Racts with Human 32 kDa OLIG2 protein. Cross reacts with proteins from Mouse, Rat and other species.
Formulation	0.1M Tris 0.1M Glycine, 2% Sucrose State: Purified State: Lyophilized purified antibody Preservative: None
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store the antibody at -20°C. Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer Avoid repeated freezing and thawing.
Gene Name	oligodendrocyte lineage transcription factor 2
Database Link	Entrez Gene 10215 Human UniProt ID Q13516
Background	Olig2 is a transcription factor which is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Expressed in the ventral spinal cord as early as 9.5 dpc and scattered in the mantle zone, likely corresponding to oligodendrocyte progenitors migrating out from their site of origin. From 10.5 through 14.5 dpc, Olig2 is expressed in numerous cells in the ventricular and subventricular zones of the lateral and medial ganglionic eminences, suggesting that expression might not be limited to the oligodendrocytic lineage. Olig2 has further been shown to be critical in the proliferation of malignant glioma in brain tumors (Ligon et al., 2007).
Synonyms	OLIG2, BHLHB1, PRKCBP2, RACK17, Oligodendrocyte transcription factor 2, Oligo2, bHLHB1
Reference Data

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