GABA A Receptor beta 3 (GABRB3) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	Peptide ELISA: 1/8000. Immunohistochemistry on paraffin sections: Human Cortex shows patchy staining near or at the neuronal cell membrane. Recommended concentration: 2-4µg/ml.
Reactivity	Bovine, Canine, Human, Mouse, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-EKTAKAKNDRSK, from the internal region of the protein sequence according to NP_000805.1; NP_068712.1.
Specificity	This antibody reacts to GABRB3.
Formulation	Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	gamma-aminobutyric acid type A receptor beta3 subunit
Database Link	Entrez Gene 14402 MouseEntrez Gene 24922 RatEntrez Gene 2562 Human UniProt ID P28472
Background	GABA A Receptor beta 3 is one of at least 13 distinct subunits of a multisubunit chloride channel that serves as the receptor for gamma-aminobutyric acid, the major inhibitory transmitter of the nervous system. The GABAA receptor complex is the molecular target of the benzodiazepine class of tranquilizer drugs, and hence it is also often referred to as the 'benzodiazepine receptor'. The GABAA receptor complex also appears to have distinct binding sites for a variety of other pharmaco-active compounds.
Synonyms	GABRB-3, GABA A receptor subunit beta-3
Reference Data
Protein Families	Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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