Xanthine Oxidase (XDH) Guinea Pig Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western BLot: 1/2000 (ECL). Immunohistochemistry on Frozen Sections: 1/100-1/200. Immunohistochemistry on Paraffin Sections: 1/100-1/200 (Microwave treatment required). Incubation Time: 1 h at RT for immunohistochemistry.
Reactivity	Bovine, Human, Mouse, Rat
Host	Guinea Pig
Clonality	Polyclonal
Immunogen	Xanthine Oxidase purified from Bovine Milk Fat Globule Membrane (MFGM).
Specificity	The antiserum reacts specifically with Xanthine Oxidase, a 150 kD polypeptide present in lactating mammary gland epithelium and in MFGM. No cross-reaction with other MFGM proteins.
Formulation	State: Serum State: Liquid Serum with 0.5 % BSA Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted short term at 2-8°C. Long term storage in aliquots at -20°C. Avoid freeze/thaw cylces.
Gene Name	xanthine dehydrogenase
Database Link	Entrez Gene 22436 MouseEntrez Gene 497811 RatEntrez Gene 7498 Human UniProt ID P47989
Background	In normal tissues this enzyme exists predominantly as Xanthine Dehydrogenase which converts hypoxanthine and xanthine to uric acid, a critical plasma antioxidant. During ischemia, Xanthine Dehydrogenase is reversibly converted to the oxygen radical-producing Xanthine Oxidase by oxidation of essential sulfhydryl groups, or irreversibly, through limited proteolytic cleavage of the amino-terminus. Aldehyde Oxidase has a higher affinity for aldehydes than purines, but produces O2- in a manner very similar to Xanthine Oxidase because both oxidases possess nearly identical internal electron transport systems.  Xanthine oxidase 150 kD polypeptide is present in the apical membrane of lactating mammary epithelium and in MFGM.
Synonyms	Xanthine dehydrogenase/oxidase
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism

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