TrkA (NTRK1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF
Recommend Dilution	Immunofluorescence: 1/100-1/200.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH-Peptide sequence around aa.789~793 (P-V-Y-L-D) derived from Human TrkA.
Specificity	This antibody detects endogenous levels of total TrkA protein.
Formulation	PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	neurotrophic receptor tyrosine kinase 1
Database Link	Entrez Gene 4914 Human UniProt ID P04629
Background	The Trk proto-oncogene family contains four members, TrkA, TrkB, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins. Phosphorylation at Tyr490 is required for Shc association and subsequent activation of the Ras-MAP kinase-signaling cascade, which leads to activation of Elk-1-dependent gene transcription and neurite growth. Phosphorylations at Tyr674 and Tyr675 lie within the catalytic domain of TrkA tyrosine kinase and reflect Trk kinase activity. Additionally, phosphorylation at Tyr751 is required for PI3-kinase association and activation of the Akt signaling cascade.
Synonyms	NTRK1, TRK, Trk-A
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways	Apoptosis, Endocytosis, MAPK signaling pathway, Neurotrophin signaling pathway, Pathways in cancer, Thyroid cancer

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