PPP1R14A (Isoform alpha) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF
Recommend Dilution	Immunofluorescence: 1/100 - 1/200.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthesized non-phosphopeptide derived from human CPI17α around the phosphorylation site of threonine 38 (R-V-TP-V-K)
Specificity	CPI17α antibody detects endogenous levels of total CPI17α protein.
Formulation	Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol State: Aff - Purified State: Liquid purified Ig
Concentration	lot specific
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	protein phosphatase 1 regulatory inhibitor subunit 14A
Database Link	Entrez Gene 68458 MouseEntrez Gene 114004 RatEntrez Gene 94274 Human UniProt ID Q96A00
Background	PKC potentiated inhibitor protein-17 is a 17kDa protein. Expressed in smooth muscles and neuronal cells, CP117 is a myosin phosphatase inhibitor protein. Phosphorylation of CP117 at Thr38 enhances its inhibitory effect by 100 fold. Once phosphorylated, CP117 inhibits PP1c and MLCP holoenzyme activity.
Synonyms	Protein phosphatase 1 regulatory subunit 14A, CPI-17, CPI17, PPP1INL
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Vascular smooth muscle contraction

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