MARK2 pThr595 Rabbit Polyclonal Antibody
CAT#: AP09297PU-N
MARK2 pThr595 rabbit polyclonal antibody, Aff - Purified
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CNY 8,025.00
货期*
4周
规格
Specifications
Product Data | |
Applications | ELISA, WB |
Recommend Dilution | ELISA: 1/1,000 - 1/3,000. Western Blot: 1/250 - 1/1,000. |
Reactivity | Bovine, Canine, Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to amino acids surrounding T595 of Human MARK2 isoform a. The immunogen peptide was phosphorylated at the residue corresponding to T595 |
Specificity | This antibody is directed against the phosphorylated form of MARK2 at thepT595 residue. |
Formulation | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01% (w/v) Sodium Azide State: Aff - Purified State: Liquid purified Ig |
Concentration | lot specific |
Purification | Affinity chromatography |
Conjugation | Unconjugated |
Storage Condition | Store the antibody at -20°C. Avoid repeated freezing and thawing. |
Gene Name | microtubule affinity regulating kinase 2 |
Database Link | |
Background | This antibody recognizes a regulatory phosphorylation on a kinase that is critical to regulation of microtubules, cell cycle and immune responses. MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens]. EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encode two isoforms of the human ser/thr protein kinase EMK1 called MARK2. These isoforms were characterized by the presence of a 162-bp alternative exon that gives rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be co-expressed in a number of selected cell lines and tissue samples. Human MARK2 was shown to be encoded by a single mRNA that is ubiquitously expressed. This transcription variant includes the alternative exon in the coding region and therefore codes for a longer protein. Multiple splice variants exist for this protein. |
Synonyms | Serine/threonine-protein kinase, 2, ELKL motif kinase, EMK1, PAR1 homolog, MARK2, EMK1 |
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