FANCF Rabbit Polyclonal Antibody
CAT#: AP09249PU-N
FANCF rabbit polyclonal antibody, Aff - Purified
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CNY 8,025.00
货期*
4周
规格
Specifications
Product Data | |
Applications | ELISA, WB |
Recommend Dilution | ELISA: 1:15,000 - 1:60,000. Western blot: 1:1,000 - 1:5,000 (Expect a band approximately 42 kDa in size corresponding to FANCF in the appropriate human tissue). |
Reactivity | Chimpanzee, Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to an internal amino acid sequence of human FANCF |
Specificity | This affinity purified antibody is directed against FANCF protein. |
Formulation | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide State: Aff - Purified State: Liquid sterile filtered Ig fraction |
Concentration | lot specific |
Purification | Immunoaffinity chromatography |
Conjugation | Unconjugated |
Storage Condition | Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use. |
Gene Name | Fanconi anemia complementation group F |
Database Link | |
Background | FANCF (also called Protein FACF or Fanconi Anemia Group F protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCF has also been implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. FANCF belongs to the multi-subunit Fanconi Anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. FANCF is found within the nucleus. Defects in FANCF are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopaenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level, it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair. |
Synonyms | Fanconi anemia group F protein, FACF |
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