IL7R alpha (IL7R) pTyr449 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/100000. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 1/1000 - 1/10000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to residues near Tyr449 of Mouse IL-7 protein
Specificity	This antibody recognizes Interleukin 7 Receptor Alpha Chain (IL7R). This phospho-specific polyclonal antibody reacts with Mouse IL-7 pY449 and shows minimal reactivity by ELISA against the non-phosphorylated form of the immunizing peptide.
Formulation	0.02M Potassium Phosphate, pH 7.2 with 0.15 M Sodium Chloride State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.01% Sodium Azide
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	interleukin 7 receptor
Database Link	Entrez Gene 3575 Human UniProt ID P16871
Background	Interleukin 7 Receptor (IL7R) is a receptor for interleukin 7 (IL7). The function of IL7R requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
Synonyms	Interleukin-7 receptor subunit alpha, IL-7R-alpha, IL7 receptor alpha
Reference Data

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