NOTCH3 (C-term) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	ELISA: 1/16000. Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Reactivity	Human, Mouse, Rat, Bat, Monkey
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from C-terminus of Human NOTCH3
Specificity	Recognizes Notch Homolog 3 (NOTCH3) at aa 2306-2318.
Formulation	Tris Saline Buffer, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	notch 3
Database Link	Entrez Gene 4854 Human UniProt ID Q9UM47
Background	NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Synonyms	Notch-3
Reference Data

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