Ionotropic Glutamate receptor 2 (GRIA2) (+ GLUR3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1/1000.
Reactivity	Chicken, Human, Mouse, Rat, Zebrafish
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide corresponding to amino acid residues from the C-terminal region of rat GluR2/3.
Specificity	This antibody is specific for endogenous levels of the ~100 kDa GluR2/3 protein.
Formulation	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% Glycerol. State: Aff - Purified State: Liquid purified Ig fraction.
Purification	Affinity Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	glutamate ionotropic receptor AMPA type subunit 2
Database Link	Entrez Gene 14800 MouseEntrez Gene 29627 RatEntrez Gene 2891 Human UniProt ID P42262
Background	The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by -amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990;Hollmann and Heinemann, 1994). The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory (Duprat et al., 2003;Seidenman et al., 2003;Chung et al., 2003;Yan et al., 2002).
Synonyms	GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA2, GRIA2
Reference Data
Protein Families	Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane
Protein Pathways	Amyotrophic lateral sclerosis (ALS), Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction

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