Transferrin (TF) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IP
Recommend Dilution	Suitable for use in Immunoprecipitation and ELISA (1/1,000-1/10,000).
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Purified human transferrin.
Specificity	This antibody is specific for Transferrin (TF).
Formulation	PBS, pH 7.4 containing 0.05% Sodium Azide as preservative and 1% BSA as stabilizer. State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Protein A Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	transferrin
Database Link	Entrez Gene 7018 Human UniProt ID P02787
Background	Transferrin is a blood plasma protein for iron ion delivery. It is a is a glycoprotein, which binds iron very tightly but reversibly. Transferrin has a molecular weight of around 80 kilo Daltons and contains 2 specific high affinity Fe (III) binding sites. It is synthesized in the liver and consists of two domains each having a high affinity reversible binding site for Fe3+. The iron is transported in blood and interstitial fluids to sites of use and disposal. Iron/Transferrin is essential in hemoglobin synthesis and for certain types of cell division. Serum concentration rises in iron deficiency and pregnancy and falls in iron overload, infection and inflammatory conditions. When a transferrin protein loaded with iron encounters a transferrin receptor on the surface of a cell (importantly, to erythroid precursors in the bone marrow), it binds to it and is consequently transported into the cell in a vesicle.
Synonyms	Serotransferrin, Siderophilin
Reference Data

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