S100A1 Rabbit Polyclonal Antibody

CAT#: AP08126PU-N

S100A1 rabbit polyclonal antibody, Purified

Size: 500 ul 1 ml



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CNY 4,928.00


货期*
5周

规格
    • 1 ml

Product images

Specifications

Product Data
Applications IF, IHC
Recommend Dilution Suitable for Immunohistochemistry and Immunocytochemistry (Frozen or Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections and cell smears): 1/50-1/200 using streptavidin~biotin system or polymer system.
Immunofluorescence.
This antibody should not be diluted in buffer which contains detergents.
Positive control: Melanoma or schwannoma.
Reactivity Bovine, Human, Monkey, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Purified S100 protein from Bovine.
Specificity This antibody stains schwannoma, ependymomas, astrogliomas, almost all benign and malignant melanoma and their metasis.
Cellular localization: Cytoplasmic.
Formulation 10 mM PO4, 150 mM NaCl, pH 7.4 containing 1% BSA and 0.05% Sodium Azide as preservative.
State: Purified
State: Liquid purified Ig fraction.
Concentration lot specific
Purification Protein A Chromatography
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C.
Gene Name S100 calcium binding protein A1
Background S100 protein is a type of low molecular weight protein found in vertebrates characterized by two calcium binding sites of the helix-loop-helix ("EF-hand type") conformation. There are at least 21 different types of S100 proteins. The name is derived from the fact that the protein is 100% Soluble in ammonium sulfate at neutral pH. Most S100 proteins are homodimeric, consisting of two identical polypeptides held together by non-covalent bonds. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. Although S100 proteins are structurally similar to calmodulin, they differ in that they are cell-specific, expressed in particular cells at different levels depending on environmental factors. To contrast, calmodulin is a ubiquitous and universal intracellular Ca++ receptor widely expressed in many cells.S-100 is normally present in cells derived from the neural crest (Schwann cells, melanocytes, and glia cells), chondrocyte, adipocytes, myoepithelial cells, macrophages, Langerhans cells, dendritic cells, and keratinocytes. It may be present in some breast epithelial cells.
Synonyms S100 Calcium binding protein, S-100 protein, S100A, S100B, S-100 protein alpha chain, S-100 protein beta chain, Astrocyte Marker
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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