Nav1.5 (SCN5A) (1548-1558) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	ELISA: 1/32000. Immunohistochemistry on Paraffin Sections: 5 - 10 µg/ml.
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from an internal region of human SCN5A / Nav1.5 (NP_932173.1; NP_000326.2; NP_001092874.1; NP_001092875.1; NP_001153632.1; NP_001153633.1)
Specificity	Recognizes Human SCN5A / Nav1.5. This antibody is expected to recognize all reported isoforms (NP_932173.1; NP_000326.2; NP_001092874.1; NP_001092875.1).
Formulation	Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide State: Aff - Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	sodium voltage-gated channel alpha subunit 5
Database Link	Entrez Gene 6331 Human UniProt ID Q14524
Background	Scn5a encodes the alpha subunit of the type V voltage-gated sodium channel. These channels, composed of one alpha and one or two beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials. The alpha subunit alone has been shown to generate a functional channel in vitro, but it's kinetic properties are modulated by beta subunits. The type V channel has been shown to be tetrodotoxin-resistant. Scn5a null mice experience intrauterine lethality. Mutations in the SCN5A gene are responsible for several heart conditions, including the chromosome 3-linked form of long LQT and Brugada syndrome.
Synonyms	HB1, HB2, HH1, HBBD, CDCD2, Nav1.5, LQT3
Reference Data

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