Artemis (DCLRE1C) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/10000 - 1/20000. Immunohistochemistry on Paraffin Sections: 1.25 - 2.5 µg/ml. Western Blot: 1/500 - 1/2000.
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic Peptide corresponding to aa 482-495 of Human ARTEMIS (DCLRE1C DNA cross-link repair 1C).
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Immunoaffinity Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody (in aliquots) at -20°C. Dilute only prior to immediate use. Avoid cycles of freezing and thawing.
Gene Name	DNA cross-link repair 1C
Database Link	Entrez Gene 64421 Human UniProt ID Q96SD1
Background	Human Artemis is a newly identified 78.4 kDa, novel DNA double-strand break repair/v(d)j recombination protein. This gene is located at human chromosome 10. Artemis has a role in T and B lymphocyte immunodeficiency and in predisposition to lymphoma through the NHEJ pathway of DNA repair. DNA-PKcs regulates Artemis by both phosphorylation and complex formation to permit enzymatic activities that are critical for the hairpin-opening step of V(D)J recombination and for the 5' and 3' overhang processing in non-homologous DNA end joining.
Synonyms	DCLRE1C, ASCID, SCIDA, SNM1C, SNM1-like protein, A-SCID protein
Reference Data

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