ARFBP1 (HUWE1) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 2 µg/ml.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a 19 amino acid peptide from near the carboxy terminus of ARF-BP1.
Specificity	This antibody is specific to HUWE1/ARFBP1.
Formulation	PBS containing 0.02% Sodium Azide as preservative State: Aff - Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Gene Name	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Database Link	Entrez Gene 10075 Human UniProt ID Q7Z6Z7
Background	ARFBP1 is a novel E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Also ubiquitinates the p53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.
Synonyms	URE-binding protein 1, URE-B1, Mule, ARF-BP1, LASU1, HectH9, KIAA0312, KIAA1578, HSPC272
Reference Data

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