UBP43 (USP18) Rabbit Polyclonal Antibody
CAT#: AP07181PU-N
UBP43 (USP18) rabbit polyclonal antibody, Aff - Purified
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CNY 6,116.00
货期*
5周
规格
Specifications
Product Data | |
Applications | ELISA, IF, IHC, WB |
Recommend Dilution | ELISA: 1/10000 - 1/50000. Immunofluorescence. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 1/500 - 1/2000. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide |
Specificity | This antibody reacts to amino acids 40 to 49 of human USP18. |
Formulation | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide State: Aff - Purified State: Liqudi purified Ig |
Concentration | lot specific |
Purification | Immunoaffinity Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store the antibody at -20°C. Avoid repeated freezing and thawing. |
Gene Name | ubiquitin specific peptidase 18 |
Database Link | |
Background | UBP43 (also known as ISG43, Ubl thiolesterase 18, ISG15-specific processing protease, 43 kDa ISG15-specific protease, ubiquitin specific protease 18 or USP18) is a member of the deubiquitinating protease family of enzymes, which removes ubiquitin adducts from a broad range of protein substrates. Deletion of the UBP43 gene in mouse leads to a massive increase of ISG15 conjugates in tissues indicating that UBP43 is a major ISG15-specific protease. UBP43 is the first ISG15-specific protease reported. Both ISG15 and UBP43 genes are known to be strongly induced by interferon, genotoxic stress, and viral infection. Thus UBP43 may be necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms. |
Synonyms | Ubl carboxyl-terminal hydrolase 18, ISG43 |
Reference Data |
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