FANCD2 Rabbit Polyclonal Antibody

CAT#: AP06115PU-N

FANCD2 rabbit polyclonal antibody, Aff - Purified



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CNY 4,640.00


货期*
2周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution

Western blot: 1/500-1/1000.
Immunohistochemistry on Paraffin sections: 1/50-1/200.

Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to amino acids 182-234 of Human FANCD2.
Specificity This antibody detects endogenous levels of FANCD2 protein (region surrounding Pro216).
Formulation Phosphate buffered saline (PBS), pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.05% Sodium azide
Concentration 1.0 mg/ml
Purification Affinity-chromatography using epitope-specific immunogen (> 95% pure by SDS-PAGE).
Conjugation Unconjugated
Storage Condition

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Predicted Protein Size ~166 kDa
Gene Name Fanconi anemia complementation group D2
Background The Fanconi anemia (FA) proteins lack sequence homologies or motifs that could point to a molecular function. Phosphorylation of FANC(Fanconi anemia complementation group) proteins are thought to be important for the function of the FA pathway. Several FA proteins, including FANCA, FANCC, FANCF, and FANCG, interact in a nuclear complex, and this complex is required for the activation (monoubiquitination) of the downstream FANCD2 protein. When monoubiquitinated, the FANCD2 protein co-localizes with the breast cancer susceptibility protein BRCA1 in DNA damage induced foci. In male meiosis, FANCD2 also co-localizes with BRCA1 at synaptonemal complexes. The human FANCD2 gene maps to chromosome 3p25.3, contains 44 exons and encodes a 1,451 amino acid nuclear protein that exists as two protein isoforms.
Synonyms Fanconi anemia group D2 protein, FACD2, FACD
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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