FANCD2 Rabbit Polyclonal Antibody
CAT#: AP06115PU-N
FANCD2 rabbit polyclonal antibody, Aff - Purified
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CNY 4,640.00
货期*
2周
规格
Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | Western blot: 1/500-1/1000. |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to amino acids 182-234 of Human FANCD2. |
Specificity | This antibody detects endogenous levels of FANCD2 protein (region surrounding Pro216). |
Formulation | Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% Sodium azide |
Concentration | 1.0 mg/ml |
Purification | Affinity-chromatography using epitope-specific immunogen (> 95% pure by SDS-PAGE). |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Predicted Protein Size | ~166 kDa |
Gene Name | Fanconi anemia complementation group D2 |
Database Link | |
Background | The Fanconi anemia (FA) proteins lack sequence homologies or motifs that could point to a molecular function. Phosphorylation of FANC(Fanconi anemia complementation group) proteins are thought to be important for the function of the FA pathway. Several FA proteins, including FANCA, FANCC, FANCF, and FANCG, interact in a nuclear complex, and this complex is required for the activation (monoubiquitination) of the downstream FANCD2 protein. When monoubiquitinated, the FANCD2 protein co-localizes with the breast cancer susceptibility protein BRCA1 in DNA damage induced foci. In male meiosis, FANCD2 also co-localizes with BRCA1 at synaptonemal complexes. The human FANCD2 gene maps to chromosome 3p25.3, contains 44 exons and encodes a 1,451 amino acid nuclear protein that exists as two protein isoforms. |
Synonyms | Fanconi anemia group D2 protein, FACD2, FACD |
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