Ionotropic Glutamate receptor 2 (GRIA2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 1:1000; detects a band of approximately 100 kDa in rat brain hippocampus cell lysates.
Reactivity	Chicken, Human, Monkey, Mouse, Rat, Zebrafish
Host	Rabbit
Clonality	Polyclonal
Immunogen	Keyhole limpet haemocyanin conjugated synthetic peptide corresponding to an amino acid sequence within rat GluR2.
Specificity	This antibody is specific for glutamate receptor subunit 2 (GluR2), a component of the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid) group of ionotropic glutamate receptors, which play a key role at excitatory synapses, including synaptic transmission, stabilisation and plasticity.
Formulation	10mM Hepes, pH7.5 containing 0.09% Sodium Azide, 0.01% Bovine Serum Albumin, 50% Glycerol State: Purified State: Liquid purified Ig
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	glutamate ionotropic receptor AMPA type subunit 2
Database Link	Entrez Gene 2891 Human UniProt ID P42262
Background	GluR2 is possibly the most important of the AMPA receptor subunits, responsible for AMPA receptor rectifying properties, control of ion flow and in particular the influx of calcium. The majority of GluR2 in the CNS is expressed in the GluR2(R) form, containing a critical arginine residue (as opposed to a glutamine residue) in the Transmembrane region 2 (TM2) domain, thereby rendering native AMPA receptors impermeable to calcium.
Synonyms	GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA2, GRIA2
Reference Data

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