DDC Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 1/1000. This antibody detects a band of approximately 55kDa in rat adrenal medulla.
Reactivity	Bovine, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	SDS denatured, recombinant bovine DOPA decarboxylase expressed E. coli and purified from inclusion bodies.
Specificity	This antibody recognises DOPA decarboxylase (aromatic-L-amino acid decarboxylase, DDC).
Formulation	10mM HEPES pH7.5, 150mM NaCl containing 0.09% Sodium Azide as preservative and 0.01% BSA, 50% Glycerol as stabilizer. State: Purified State: Liquid purified IgG fraction.
Purification	Affinity Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Database Link	Entrez Gene 280762 Bovine UniProt ID P27718
Background	DOPA decarboxylase is an enzyme implicated in 2 metabolic pathways, synthesizing 2 important neurotransmitters: dopamine and serotonin which both play key roles in many clinical disorders, including Parkinson's disease. Following the hydroxylation of tyrosine to form L dihydroxyphenylalanine (LDOPA), catalyzed by tyrosine hydroxylase, DDC decarboxylates LDOPA to form dopamine. This neurotransmitter is found in different areas of the brain and is particularly abundant in basal ganglia. Dopamine is also produced by DDC in the sympathetic nervous system and is the precursor of the catecholaminergic hormones, noradrenaline and adrenaline in the adrenal medulla. In the nervous system, tryptophan hydroxylase produces 5 OH tryptophan, which is decarboxylated by DDC, giving rise to serotonin. DDC is a homodimeric, pyridoxal phosphate dependent enzyme.
Synonyms	DOPA decarboxylase
Reference Data

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