CCK4 (PTK7) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 0.5 - 1.0 µg/ml; detects a band of approximately 86kDa in colon tissue lysates. Immunohistochemistry on paraffin sections (requires antigen retrieval using heat treatment prior to staining).
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A 15 amino acid peptide located near the N-terminal region of human PTK7.
Specificity	This antibody recognises Protein tyrosine kinase-like 7 (PTK7).
Formulation	Phosphate buffered saline containing 0.02% Sodium Azide State: Purified State: Liquid purified IgG
Concentration	lot specific
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	protein tyrosine kinase 7 (inactive)
Database Link	Entrez Gene 5754 Human UniProt ID Q13308
Background	PTK7 is a member of the receptor tyrosine kinase family, otherwise known as Colon Carcinoma Kinase 4 (CCK4). PTK7 is highly expressed in the kidney, liver, lung, pancreas and melanocytes with weaker expression being detected in the thyroid gland, ovaries, brain, heart and skeletal muscle. PTK7 may play a role in embryonic development. It is thought to function as a cell adhesion molecule and as a novel regulator of the planar cell polarity (PCP) pathway in vertebrates. Studies also suggest that PTK7 may be involved in the tumour progression. A loss of PTK7 expression has been observed in melanoma cell lines, whereas increased levels of PTK7 have been detected in high-throughput acute myeloid leukaemia samples. In addition, PTK7 is not expressed in normal colon but has been detected in colon carcinomas and as such is a potential marker for tumour progression.
Synonyms	Tyrosine-protein kinase-like 7, Colon carcinoma kinase 4, CCK-4
Reference Data

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