RNF34 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ELISA: 1800 - 1:4000. Western Blot: 1:100 - 1:600; detects a band of approximately 42kDa.
Reactivity	Bovine, Canine, Human, Mouse, Primate, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein corresponding to amino acids 1-373 of human RFI.
Specificity	This antibody detects Ring Finger homologous to Inhibitor of apoptosis protein (hRFI).
Formulation	Phosphate buffered saline pH7.2 containing 0.01% Sodium Azide (NaN3) State: Purified State: Liquid purified IgG
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	ring finger protein 34
Database Link	Entrez Gene 80751 MouseEntrez Gene 282845 RatEntrez Gene 80196 Human UniProt ID Q969K3
Background	RFI is an anti-apoptotic protein which has been shown to be a novel modulator of NF-kB activation, leading to the upregulation of Bcl2 and BclXL. It is also thought to possess E3 ubiquitin protein ligase activity and has been shown to target caspases 8 and 10 for proteasomal degradation. hRFI is expressed ubiquitously, and has been localized to both the nucleus and the cytoplasm. hRFI is also expressed in oesophageal, gastric and colorectal cancers, suggesting a possible association between hRFI and the development of digestive tract cancers.
Synonyms	CARP1, CARP-1, RIFF
Reference Data
Protein Families	Druggable Genome

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