MEK5 (MAP2K5) pSer311/pThr315 Rabbit Polyclonal Antibody

CAT#: AP05673PU-N

MEK5 (MAP2K5) pSer311/pThr315 rabbit polyclonal antibody, Purified



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CNY 8,351.00


货期*
4周

规格
    • 100 ul

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Specifications

Product Data
Applications WB
Recommend Dilution Western Blot: 1:1000; detects a band of approximately 49kDa in rat testes cell lysates.
Reactivity Bovine, Canine, Chicken, Human, Monkey, Mouse, Rat, Xenopus, Zebrafish
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic phosphopeptide corresponding to an amino acid sequence within MEK5 , which includes phoshorylated Ser311 and Thr315.
Specificity This antibody specifically recognises 49kDa MEK5, also known as MAP2K5, when phosphorylated at Ser311 and Thr315.
Activation of MEK5 itself is regulated by upstream MAP3K3/MEKK3, and phosphorylation of MEK5 at both the Ser311 and Thr315 sites has been implicated in cell proliferation.
Formulation 10mM Hepes pH7.5 containing 0.09% Sodium Azide (NaN3), 0.01% Bovine Serum Albumin, 50% Glycerol
State: Purified
State: Liquid purified IgG
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name mitogen-activated protein kinase kinase 5
Background MEK5 is a dual specificity serine/threonine protein kinase belonging to the MAP kinase kinase family, which acts as a key regulator in a mitogen-activated protein (MAP) kinase cascade, and hence growth factor-induced cellular stimulation. MEK5 exists in naturally occurring MEK5alpha and MEK5beta splice variants, the former of which is known to specifically activate/regulate MAPK7/ERK5/BMK1, whilst the latter may act as a suppressor of MAPK7 activation.
Synonyms MAP kinase kinase 5, MAPKK 5, MEK5, MKK5
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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