Cardiac Troponin I (TNNI3) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	ELISA.
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Native human cardiac troponin I, purity greater than 98%.
Specificity	This antibody recognises human cardiac-specific troponin I, (TnI) an integral inhibitory protein of cardiac muscle which exists as a complex with troponin C (TnC) and troponin T (TnT).
Formulation	PBS buffer pH 7.4 containing 0.09% Sodium Azide (NaN3) State: Purified State: Liquid purified IgG
Concentration	lot specific
Purification	Immunoaffinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	troponin I3, cardiac type
Database Link	Entrez Gene 7137 Human UniProt ID P19429
Background	The TnT subunit of troponin binds to tropomyosin to form a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, enabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage, and can be used to differentiate between angina and myocardic infarction in patients with chest pain. Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro.
Synonyms	TNNI3, TNNC1
Reference Data

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